People seem to be fixing on sf, maybe because the future catches up with "predictions", but I can't really buy that. People went on reading stuff like Wells and early Heinlein (or Shelly, for that matter) long after it was clear that their future was not our future.

My choice is comedy, because comedy depends on social cues that will read very differently across the generations, and because the comic response is fairly limited in its nature. A drama may be emotionally powerful for a number of reasons, but something is either funny or it's not.